NANOKINE

COMPOSITION

NANOKINE 2000 IU/Vial of Solution for injection

Each vial of 1 mL contains:

Active ingredient: Recombinant Human Erythropoietin alfa..............2000 IU

Excipients: Sodium Citrate, Sodium Chloride, Citric Acid, Polysorbate 80, Benzyl Alcohol, Water for Injection.

NANOKINE 2000 IU/Prefilled syringe

Each prefilled syringe of 0.5 mL contains:

Active ingredient: Recombinant Human Erythropoietin alfa..............2000 IU

Excipients: Sodium Citrate, Sodium Chloride, Citric Acid, Polysorbate 80, Benzyl Alcohol, Water for Injection.

NANOKINE 4000 IU/Vial of Solution for injection

Each vial of 1 mL contains:

Active ingredient: Recombinant Human Erythropoietin alfa..............4000 IU

Excipients: Sodium Citrate, Sodium Chloride, Citric Acid, Polysorbate 80, Benzyl Alcohol, Water for Injection.

NANOKINE 4000 IU/Prefilled syringe

Each prefilled syringe of 0.5 mL contains:

Active ingredient: Recombinant Human Erythropoietin alfa..............4000 IU

Excipients: Sodium Citrate, Sodium Chloride, Citric Acid, Polysorbate 80, Benzyl Alcohol, Water for Injection.

NANOKINE 10000 IU/Prefilled syringe

Each prefilled syringe of 1 mL contains:

Active ingredient: Recombinant Human Erythropoietin alfa..............10000 IU

Excipients: Sodium Citrate, Sodium Chloride, Citric Acid, Polysorbate 80, Benzyl Alcohol, Water for Injection.

DESCRIPTION

NANOKINE is produced from raw, high purity materials erythropoietin (EPO). The EPO is produced by recombinant DNA techniques on ovarian cell lines marsupial cheeks of China (Chinese Hamster ovary, CHO). EPO gene coding for the protein was transferred into CHO cells (no gene EPO). CHO cell lines were cultured EPO gene in specific environments to produce EPO.

Erythropoietin alfa is Recombinant Human Erythropoietin, contains 165 amino acids. Recombinant Human Erythropoietin and Erythropoietin completely natural sequence similarity and amino acid sequences oligosaccharide is very similar in structure carbon hydrate. Molecular group is more glycosylated. Erythropoietin has biological effects and immunology as endogenous Erythropoietin and activity of 10000 IU to 1 mg hormone.

NANOKINE is also supplied as an injectable solution in vials and prefilled syringes. Injectable solution is sterile, clear, and colorless.

Pharmacotherapeutic group: Hematopoietic agents

INDICATIONS

Treatment of symptomatic anaemia associated with chronic renal failure (CRF) in adult and paediatric (>3 years old) patients :

Treatment of symptomatic anaemia associated with chronic renal failure paediatric and adult patients on haemodialysis and adult patients on peritoneal dialysis.
Treatment of severe amaemua of renal origin accompanied by clinical symptoms in adult patients with renal insufficiency not yet undergoing dialysis.

Treatment of amaenia and reduction of transfusion requirements in adults patients receiving chemotherapy for solid tumours, malignant lymphoma or multiple myeloma, and at risk of transfusion as assessed by the patient's general status (e.g. cardiovascular status, pre-existing amaemia at the start of chemotherapy).

CONTRAINDICATIONS

Patients who develop pure red cell aplasia (PRCA) following treatment with Erythropoietin should not receive NANOKINE or any other Erythropoietin.
Uncontrolled hypertension.
All contraindications associated with autologous blood predonation programmes should be respected in patients being supplemented with Erythropoietin alfa.
Hypersensitivity to the active substance or to any of the excipients.

STORAGE, SHELF LIFE, PACKING UNITS

Storage:

Store in the refrigerator at 2^oC - 8^oC. Do not freeze. Protect from light.

Shelf life:

24 months from manufacturing date.

Packing units:

Box of 1 vial of solution for injection NANOKINE 2000 IU or 4000 IU (1 mL)

Box of 1 prefilled syringe of solution for injection NANOKINE 2000 IU or 4000 IU (0.5 mL)

Box of 1 prefilled syringe of solution for injection NANOKINE 10000 IU (1 mL)

NANOKINE

NANOKINE

NANOKINE

NANOKINE

NANOKINE

NANOKINE

NANOKINE

Related products

FICOCYTE

PEGCYTE

PEGNANO

FERONSURE